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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Annu Rev Biomed Eng. 2016 Feb 5;18:125–158. doi: 10.1146/annurev-bioeng-112315-031200

Figure 5.

Figure 5

Lymph node anatomy and lymphatic metastasis. Tumor-draining lymphatic vessels are remodeled by the tumor, causing cancer to spread through the lymphatic vessels to lymph nodes. The primary tumor is also able to precondition tumor-draining lymph nodes, both altering the ability of the lymph node to mount an immune response and potentially making the lymph node microenvironment more conducive to cancer growth. Metastatic lesions that form in the lymph node lack high endothelial venules and are devoid of lymphocytes. These attributes make it challenging for the lymph node to generate and sustain antitumor immunity.