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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Magn Reson Imaging. 2016 Apr 22;34(7):1034–1040. doi: 10.1016/j.mri.2016.04.014

Table 2.

Pharmacokinetic parameters of Gd-DTPA after i.v. injection of bolus of 0.025 mmol/Kg for 58 healthy volunteer calculated by employing a non-compartment model.

PK Parameter Estimate SE 95% boott-CI
AUC0-to-24 (mmol.min/L) 1.078 0.0091 (1.067; 1.09)
AUC0-to-infinity (mmol.min/L) 3.3725 0.4658       (2.77; 4.6575)
AUMC0-to-infinity (mmol.min2/L) 181.53 57.278             (120.27; 362.413)
MRT (min)               53.82     9.5624             (41.6314; 80.305)
non-comp. half-life (min) 37.309          6.628                       (28.84; 55.6633)
CL (mmol/min)     0.0741 0.0102           (0.0516; 0.0929)
VSS (mmol)            3.9901 0.1648           (3.7043; 4.3684)

AUC = area under the time-concentration curve; AUMC = area under the first moment of time-concentration curve; CL = clearance; MRT = mean residence time; SE = standard errors; VSS = volume of distribution at steady state.