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. Author manuscript; available in PMC: 2017 Jan 14.
Published in final edited form as: Nature. 2016 Jul 14;535(7611):246–251. doi: 10.1038/nature18632

Extended Data 1. MYCN is a highly conserved let-7 target.

Extended Data 1

(a) Schematic of human MYCN ORF and 3′UTR, indicating let-7 sites 1 and 2 and their approximate location. (b) Predicted base pairing patterns of let-7a, let-7f, and let-7g with MYCN let-7 sites #1 and #2. A–G base pairs, common in RNA, are represented by (*). (c) Alignments of let-7 sites 1 and 2 in 100 vertebrate MYCN 3′UTRs (ENCODE).