Table 4.
Group | Crude HR | 95% CI | P Value | Adjusted HR | 95% CI | P Value |
---|---|---|---|---|---|---|
Overall (n=3993) | 0.93 | 0.77, 1.12 | 0.43 | 0.92 | 0.76, 1.11 | 0.38 |
Preserved kidney Function (n=3467) | 0.92 | 0.74, 1.13 | 0.42 | 0.90 | 0.73, 1.11 | 0.33 |
Stage 3-5 CKD (n=526) | 1.01 | 0.68, 1.49 | 0.98 | 0.99 | 0.67, 1.46 | 0.96 |
Stage 3a CKD (n=389) | 0.87 | 0.52, 1.45 | 0.60 | 0.79 | 0.47, 1.33 | 0.39 |
Stage 3b-5CKD (n=137) | 1.15 | 0.62, 2.13 | 0.67 | 1.29 | 0.68, 2.46 | 0.43 |
CKD with multi-vessel disease* (n=419) | 1.16 | 0.77, 1.75 | 0.49 | 1.10 | 0.73, 1.67 | 0.65 |
CKD with single-vessel disease* (n=107) | 0.33 | 0.07, 1.61 | 0.17 | 0.32 | 0.06, 1.76 | 0.19 |
CKD proximal LAD disease* (n=342) | 0.88 | 0.54, 1.43 | 0.61 | 0.94 | 0.57, 1.54 | 0.80 |
CKD without proximal LAD disease* (n=185) | 1.31 | 0.67, 2.56 | 0.43 | 1.15 | 0.57, 2.27 | 0.71 |
All models were stratified by trial. Multivariable models adjusted for treatment, age, diabetes, prior myocardial infarction, proximal left anterior descending artery disease, ejection fraction <40%, prior revascularization, and multi-vessel.
To avoid model overspecification, these subgroup models did not include terms for multi-vessel disease or proximal LAD disease, respectively. CKD-chronic kidney disease. LAD-left anterior descending artery.