Table 5.
Group | Crude HR | 95% CI | P Value | Adjusted HR | 95% CI | P Value |
---|---|---|---|---|---|---|
Overall (n=3981) | 0.90 | 0.75, 1.07 | 0.23 | 0.88 | 0.73, 1.05 | 0.16 |
Preserved kidney Function (n=3459) | 0.98 | 0.81, 1.19 | 0.87 | 0.97 | 0.80, 1.17 | 0.72 |
Stage 3-5 CKD (n=522) | 0.49 | 0.30, 0.81 | 0.01 | 0.49 | 0.29, 0.82 | 0.01 |
Stage 3a CKD (n=388) | 0.68 | 0.37, 1.27 | 0.24 | 0.71 | 0.36, 1.39 | 0.31 |
Stage 3b-5CKD (n=134) | 0.27 | 0.11, 0.66 | 0.004 | 0.23 | 0.09, 0.58 | 0.002 |
CKD with multi-vessel disease* (n=416) | 0.45 | 0.26, 0.79 | 0.01 | 0.43 | 0.24, 0.76 | 0.004 |
CKD with single vessel disease* (n=106) | 0.71 | 0.20, 2.47 | 0.59 | 1.09 | 0.24, 4.86 | 0.91 |
CKD proximal LAD disease* (n=338) | 0.39 | 0.19, 0.80 | 0.01 | 0.39 | 0.18, 0.82 | 0.01 |
CKD without proximal LAD disease* (n=183) | 0.64 | 0.31, 1.33 | 0.23 | 0.74 | 0.34, 1.64 | 0.46 |
All models were stratified by trial. Multivariable models adjusted for treatment, age, diabetes, prior myocardial infarction, proximal left anterior descending artery disease, ejection fraction <40%, prior revascularization, and multi-vessel.
To avoid model overspecification, these subgroup models did not include terms for multi-vessel disease or proximal LAD disease, respectively. CKD-chronic kidney disease. LAD-left anterior descending artery