Table 6.
Group | Crude HR | 95% CI | P Value | Adjusted HR | 95% CI | P Value |
---|---|---|---|---|---|---|
Overall (n=3912) | 0.14 | 0.12, 0.17 | <0.001 | 0.14 | 0.11, 0.17 | <0.001 |
Preserved kidney Function (n=3405) | 0.13 | 0.11, 0.16 | <0.001 | 0.13 | 0.11, 0.16 | <0.001 |
Stage 3-5 CKD (n=507) | 0.21 | 0.11, 0.40 | <0.001 | 0.21 | 0.11, 0.39 | <0.001 |
Stage 3a CKD (n=371) | 0.18 | 0.08, 0.41 | <0.001 | 0.17 | 0.08, 0.40 | <0.001 |
Stage 3b-5CKD (n=136) | 0.30 | 0.11, 0.85 | 0.02 | 0.25 | 0.09, 0.71 | 0.01 |
CKD with multi-vessel disease* (n=400) | 0.21 | 0.10, 0.46 | <0.001 | 0.21 | 0.10, 0.46 | <0.001 |
CKD with single vessel disease* (n=107) | 0.20 | 0.07, 0.62 | 0.01 | 0.19 | 0.06, 0.61 | 0.01 |
CKD proximal LAD disease* (n=329) | 0.19 | 0.09, 0.40 | <0.001 | 0.18 | 0.09, 0.38 | <0.001 |
CKD without proximal LAD disease* (n=176) | 0.25 | 0.07, 0.87 | 0.03 | 0.25 | 0.07, 0.92 | 0.04 |
All models were stratified by trial. Multivariable models adjusted for treatment, age, diabetes, prior myocardial infarction, proximal left anterior descending artery disease, ejection fraction <40%, prior revascularization, and multi-vessel.
To avoid model overspecification, these models did not include terms for multi-vessel disease or proximal LAD disease, respectively. CKD-chronic kidney disease. LAD