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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: NMR Biomed. 2016 Jan 15;30(3):10.1002/nbm.3458. doi: 10.1002/nbm.3458

Figure 1.

Figure 1

Schematic diagram of changes in water diffusivity in a tumor following an effective therapeutic agent. Changes in cellularity (left) occur with increasing molecular water mobility, measured as the apparent diffusion coefficient (ADC; right), as a tumor responds to treatment (top to bottom). As a tumor responds to therapy, an increase in extracellular space and membrane permeability occurs, which allows for increased water mobility, and is detected by diffusion-weighted MRI (DW-MRI) as an increase in ADC values. [Courtesy of ref. (18).]