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. 1974 May;37(5):578–584. doi: 10.1136/jnnp.37.5.578

Effect of carotid ligation on cerebral blood flow in baboons

2. Response to hypoxia and haemorrhagic hypertension

D Sengupta 1,2, Murray Harper 1,2,1, Bryan Jennett 1,2
PMCID: PMC494703  PMID: 4836753

Abstract

Cerebral blood flow (CBF) measurements were carried out in two groups of anaesthetized normocapnic baboons. In the first group of five animals the effect of hypoxia on the CBF before and after ipsilateral carotid artery ligation was studied. The results showed that, although after ipsilateral carotid ligation there was little change in the CBF at normal PaO2, at hypoxia there was only 20% rise in the CBF as compared with an 80% rise before the carotid ligation. In the second group of 10 animals, effects of haemorrhagic hypotension on the CBF after ipsilateral carotid artery ligation were estimated. The results indicated impairment of autoregulatory response of the cerebral circulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Harper A. M. Autoregulation of cerebral blood flow: influence of the arterial blood pressure on the blood flow through the cerebral cortex. J Neurol Neurosurg Psychiatry. 1966 Oct;29(5):398–403. doi: 10.1136/jnnp.29.5.398. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Harper A. M., Deshmukh V. D., Rowan J. O., Jennett W. B. The influence of sympathetic nervous activity on cerebral blood flow. Arch Neurol. 1972 Jul;27(1):1–6. doi: 10.1001/archneur.1972.00490130003001. [DOI] [PubMed] [Google Scholar]
  3. Hoedt-Rasmussen K., Sveinsdottir E., Lassen N. A. Regional cerebral blood flow in man determined by intra-arterial injection of radioactive inert gas. Circ Res. 1966 Mar;18(3):237–247. doi: 10.1161/01.res.18.3.237. [DOI] [PubMed] [Google Scholar]
  4. Häggendal E., Johansson B. Effects of arterial carbon dioxide tension and oxygen saturation on cerebral blood flow autoregulation in dogs. Acta Physiol Scand Suppl. 1965;258:27–53. doi: 10.1111/j.1748-1716.1965.tb03234.x. [DOI] [PubMed] [Google Scholar]
  5. Kindt G. W., Youmans J. R., Albrand O. Factors influencing the autoregulation of the cerebral blood flow during hypotension and hypertension. J Neurosurg. 1967 Mar;26(3):299–305. doi: 10.3171/jns.1967.26.3.0299. [DOI] [PubMed] [Google Scholar]
  6. Kogure K., Scheinberg P., Fujishima M., Busto R., Reinmuth O. M. Effects of hypoxia on cerebral autoregulation. Am J Physiol. 1970 Nov;219(5):1393–1396. doi: 10.1152/ajplegacy.1970.219.5.1393. [DOI] [PubMed] [Google Scholar]
  7. Kogure K., Scheinberg P., Reinmuth O. M., Fujishima M., Busto R. Mechanisms of cerebral vasodilatation in hypoxia. J Appl Physiol. 1970 Aug;29(2):223–229. doi: 10.1152/jappl.1970.29.2.223. [DOI] [PubMed] [Google Scholar]
  8. LASSEN N. A. Cerebral blood flow and oxygen consumption in man. Physiol Rev. 1959 Apr;39(2):183–238. doi: 10.1152/physrev.1959.39.2.183. [DOI] [PubMed] [Google Scholar]
  9. McDowall D. G. Interrelationships between blood oxygen tensions and cerebral blood flow. Int Anesthesiol Clin. 1966 Spring;4(1):205–219. [PubMed] [Google Scholar]
  10. Millikan C. H. Cerebral circulation: clinical concepts as effected by vascular anatomy, pathology, and pathophysiology. Clin Neurosurg. 1969;16:419–435. doi: 10.1093/neurosurgery/16.cn_suppl_1.419. [DOI] [PubMed] [Google Scholar]
  11. Nishioka H. Results of the treatment of intracranial aneurysms by occlusion of the carotid artery in the neck. J Neurosurg. 1966 Dec;25(6):660–704. doi: 10.3171/jns.1966.25.6.0660. [DOI] [PubMed] [Google Scholar]
  12. Sengupta D., Harper A. M., Deshmukh V. D., Rowan J. O., Jennett W. B. Effect of carotid artery ligation on the CO 2 response in the baboon. Eur Neurol. 1971;6(1):369–372. doi: 10.1159/000114525. [DOI] [PubMed] [Google Scholar]
  13. Sengupta D., Harper M., Jennett B. Effect of carotid ligation on cerebral blood flow in baboons. I. Response to altered arterial PCO2. J Neurol Neurosurg Psychiatry. 1973 Oct;36(5):736–741. doi: 10.1136/jnnp.36.5.736. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Symon L., Russell R. W. The development of cerebral collateral circulation following occlusion of vessels in the neck. An experimental study in baboons. J Neurol Sci. 1971 Jun;13(2):197–208. doi: 10.1016/0022-510x(71)90149-3. [DOI] [PubMed] [Google Scholar]
  15. Wilkinson I. M. Browne DR: The influence of anaesthesia and of arterial hypocapnia on regional blood flow in the normal human cerebral hemisphere. Br J Anaesth. 1970 Jun;42(6):472–482. doi: 10.1093/bja/42.6.472-a. [DOI] [PubMed] [Google Scholar]

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