Skip to main content
. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Eur Radiol. 2016 Jan 15;26(10):3474–3482. doi: 10.1007/s00330-015-4197-y

TABLE 2.

Calculated pharmacokinetic parameters for doxorubicin and doxorubicinol in plasma samples following intra-arterial injection in the left hepatic artery.

Pharmacokinetic
Parameters		 Small DEB Group
(SD)		 Large DEB Group
(SD)		 Control Group
(SD)
AUC Doxorubicin
(nM*min) 		1019.96

(767.51)		 897.13

(575.86)		 3713.87

(955.38)
Cmax Doxorubicin
(nM) 		15.15

(21.23)		 11.86

(9.02)		 60.65

(24.58)
t1/2 Doxorubicin
(min) 		236.72

(173.53)		 378.65

(538.85)		 111.44

(49.36)
Ke Doxorubicin 0.005

(0.005)		 0.005

(0.005)		 0.007

(0.002)
tomc Doxorubicin
(min) 		34

(31.34)		 29.09

(16.40)		 60

(80)
AUC Doxorubicinol
(nM*min) 		969.39

(1098.81)		 656.33

(754.26)		 6873.54

(3396.30)
Cmax
Doxorubicinol (nM) 		7.28

(8.97)		 5.60

(7.27)		 54.02

(34.07)
t1/2 Doxorubicinol
(min) 		240.43

(.)		 234.13

(230.51)		 93.49

(11.30)
Ke Doxorubicinol 0.002

(.)		 0.005

(0.004)		 0.001

(0.001)
tomc Doxorubicinol
(min) 		136

(65.86)		 132.73

(60.84)		 80

(69.28)

AUC= Area under the concentration curve, in nM* min; Cmax= maximum concentration, in nM; t1/2 =half life of drug, in min; Ke= elimination rate; tomc=time to maximum concentration, in min.