Table 2.

Patients in the prospective cohort who required hospital readmission due to the infection and changed back to IV antibiotic treatment

N	Type of infection	Causative microorganisms	Initial IV antibiotic	Oral antibiotic	Reason for readmission	Comments
1	Knee PJI	CONS	DAP	CLIN+RF	C. difficile-associated diarrhoea	Antibiotics were not reintroduced
2	Cellulitis	MRSA, GNB	VAN+CIP	COT+ CIP	Persistence of infection	Surgical debridement
3	Knee PJIa	CONS	VAN	LIN	Persistence of PJI	2-stage removal
4	Chronic osteomyelitis	CONS	TEICO	LIN+RF	Persistence of infection	New surgery
5	Knee PJIa	MRSA	DAP	LIN+RF	Persistence of PJI	2-stage removal
6	Shoulder PJIa	CONS	VAN	COT+ RF	Persistence of PJI	2-stage removal
7	Chronic osteomyelitis	CONS	TEICO	LIN	Persistence of infection+GNB superinfection	New surgery
8	Knee PJI	CONS	DAP	LIN	Persistence of infection	New surgical approach

PJI prosthetic joint infection, CONS coagulase-negative staphylococci, MRSA methicillin-resistant S. aureus, GNB gram-negative bacilli, MSSA methicillin-susceptible S. aureus (in patients with beta lactam allergy), DAP daptomycin, CLIN clindamycin, RF rifampicin, VAN vancomycin, CIP Ciprofloxacin, COT Cotrimoxazole, LIN linezolid, TEICO teicoplanin

^aThree patients diagnosed with PJI had been previously treated with debridement, antibiotics, and implant retention, but this strategy failed and all of them required prosthesis removal using a two-stage approach