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. Author manuscript; available in PMC: 2016 Jul 16.
Published in final edited form as: Gastroenterology. 2011 May;140(6):1704–1712. doi: 10.1053/j.gastro.2011.02.046

Table 2.

Comparative Associations Between Inflammatory Bowel Disease and Related Chronic Inflammatory Diseases

Loci IBD Psoriasis Celiac disease Primary sclerosing cholangitis Ankylosing spondylitis
Gene product in the IL-23 pathway Yes Yes No No Yes
Major histocompatibility complex Class II predominant Class I predominant Class II predominant Class I predominant Class I predominant
Loci of genome-wide significance shared with IBD — 4 14 3p21(a gene-rich region that includes MST1)68 2: ERAP1a at chr5p15; CARD9 at chr9q34

NOTE. The large number of loci shared between inflammatory bowel disease (IBD) and celiac disease might reflect the larger number of loci established for celiac disease, compared with psoriasis, ankylosing spondylitis, and primary sclerosing cholangitis.

IL-23, interleukin-23.

a

The association with ERAP1 is distinct from the association with Crohn's disease.