Figure 5. Comparison of CD320-bound TC with free HC (pdb ID 4KKI).

(a) Superposition of HC with CD320-bound TC revealing position of glycosylated residues (green sticks) of HC. (b) Electrostatic potential maps of CD320 (2nd from left), TC (2nd from right) and HC (right) with the latter two rotated 180° along the y axis in relation to CD320 to reveal the receptor interaction surfaces. For clarity, CD320 LDLR-A1 (yellow) and LDLR-2 (gold) are also show in cartoon format. The regions of HC corresponding to equivalent TC binding regions for LDLR-A1 and LDLR-A2 are highlighted (dotted yellow and gold ovals, respectively).