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. 2016 Jul 15;7:12096. doi: 10.1038/ncomms12096

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(a) Shown is the cumulative number of cancer genes known to be perturbed by somatic single-nucleotide variations, as recorded in the COSMIC CGC, according to the year of first cancer-related publication indexed in PubMed. Each bar is coloured by the experimental technique categories used by these first publications. In parenthesis is the number of genes associated with each experimental category as of 2013. (b) Proportion of the different types of somatic alteration included in the CGC. In blue are the proportions for all somatically altered genes; in green are the same proportions for genes also known to have single-nucleotide alterations.