Figure 4. TRPC5 participates in the pressure-sensing of rat aortic baroreceptors.

(a,b) Representative traces showing that blood pressure elevation (upper row) increased the spike frequency and magnitude of aortic depressor nerve activity (ADNA) in the left aortic depressor nerve. Integrated ADNA (Int ADNA) are also shown. The middle two rows show the spike traces and Int ADNA at low blood pressure, whereas the bottom two rows show the spike traces and Int ADNA at high blood pressure. Rats were infected with either lenti-vector (a) or lenti-T5DN (b) at the nodose ganglion. (c) Data summary comparing the baroreceptor sensitivity (Δspikes s⁻¹ ΔmmHg⁻¹), which is the change in spike frequency per mmHg pressure increase. Sham, sham-operated; Vec, vector. Mean±s.e.m. (n=6–8). *P<0.05 as compared with vector, statistical analysis was performed by Student’s t-test.