Figure 7. TRPC5 participates in the pressure-sensing of aortic baroreceptors.

(a) Representative trace showing the procedures to alter blood pressure in 129S1/SvImJ mice. Sodium nitroprusside (SNP; 1.3 μg g⁻¹ body weight) was intravenously injected, followed by phenylephrine infusion into femoral vein (Phe; 20 μg g⁻¹ body weight), which raised the blood pressure. Action potentials at the left aortic depressor nerve were recorded continuously. (b) Representative traces of the pressure-induced changes in the spike frequency, aortic depressor nerve activity (ADNA) and Int ADNA in wild-type (WT) and Trpc5^−/− (KO) mice. (c) Data summary comparing the baroreceptor sensitivity (Δspikes s⁻¹ ΔmmHg⁻¹), which is the change in spike frequency per mmHg pressure increase. Mean±s.e.m. *P<0.05 as compared with WT, statistical analysis was performed by Student’s t-test.