Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jul 15;7:12210. doi: 10.1038/ncomms12210

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

This diagram represents our current hypothesis of how asymmetric pacsin2 recruitment regulates the trafficking of the VE-cadherin at FAJs. Triggered by unbalanced actomyosin pulling forces, causing membrane curvature at the junction, pacsin2 dimers decorate around the trailing ends of fast-moving FAJs. Pacsin2 functions to inhibit VE-cadherin internalization towards Rab5-positive and Rab4-positive endosomes.