Table 2.

Association of HF (Modeled as a Time-Dependent Variable) With Subsequent Cancer Risk

		Overall	Men	Women	Age<75 Yrs at Index MI	Age ≥75 Yrs at Index MI
Cancer rate per 1,000 person-years	HF	33.7	41.0	26.4	35.9	30.3
	No HF	15.6	15.7	15.4	15.0	17.9
	p value	0.002	0.003	0.20	0.004	0.28
HR (95% CI)
Time from MI as time scale	Unadjusted	2.16 (1.39–3.35)	2.60 (1.49–4.54)	1.71 (0.84–3.49)	2.37 (1.39–4.04)	1.65 (0.74–3.69)
	Adjusted*	1.71 (1.07–2.73)	1.72 (0.95–3.14)	1.61 (0.77–3.35)	1.94 (1.11–3.41)	1.55 (0.67–3.56)
	Adjusted†	1.92 (1.11–3.31)	1.39 (0.66–2.93)	2.47 (1.08–5.66)	1.97 (0.99–3.91)	2.06 (0.74–5.73)
Age as time scale	Unadjusted	1.89 (1.21–2.97)	2.03 (1.14–3.62)	1.85 (0.89–3.84)	1.95 (1.14–3.34)	1.79 (0.80–4.01)
	Adjusted‡	1.65 (1.04–2.64)	1.72 (0.95–3.12)	1.79 (0.84–3.80)	1.64 (0.93–2.90)	1.70 (0.75–3.90)
	Adjusted§	1.84 (1.06–3.19)	1.35 (0.63–2.88)	2.79 (1.18–6.63)	1.54 (0.77–3.08)	2.29 (0.86–6.09)

^*Adjusted for age, sex, and Charlson comorbidity index (the sex-specific estimates are adjusted for age and comorbidity, whereas the age-specific estimates are adjusted for sex and comorbidity).

^†Further adjusted for hypertension, smoking, BMI, anterior MI, peak cTnt, Killip class, reperfusion/revascularization, and treatment with aspirin at hospital discharge.

^‡Adjusted for sex and Charlson comorbidity index (the age-specific estimates are adjusted for comorbidity).

^§Further adjusted for hypertension, smoking, BMI, anterior MI, peak cTnT, Killip class, reperfusion/revascularization, and treatment with aspirin at hospital discharge.

CI = confidence interval; HR = hazard ratio. Other abbreviations as in Table 1.