Table 4.

List of nsSNPs that predicted to be deleterious by both PolyPhen-2 and SIFT tools

	Gene Symbol	SNP	Allele	AA substitution	PolyPhen Score	PolyPhenPerediction	SIFT Score	SIFT prediction
1	CHUK	rs56948661	G>A	P623L	1	P.D	0.01	Damaging
2	CHUK	rs61732515	C>G	Q277H	0.999	P.D	0.00	Damaging
3	CHUK	rs112432667	T>C	E492G	0.954	P.D	0.00	Damaging
4	FOS	rs74685695	T>G	V77G	0.999	P.D	0.01	Damaging
5	IRF5	rs112815033	T>C	L450P	1	P.D	0.01	Damaging
6	IRAK4	rs55944915	G>A	R391H	0.999	P.D	0.01	Damaging
7	IRAK4	rs114820168	C>T	R391C	1	P.D	0.00	Damaging
8	MAP3K7	rs77759048	A>T	W55R	1	P.D	0.00	Damaging
9	TBK1	rs34774243	A>G	K291E	0.997	P.D	0.00	Damaging
10	TBK1	rs55824172	C>T	S151F	0.997	P.D	0.00	Damaging
11	TIRAP	rs74937157	T>C	C134R	1	P.D	0.00	Damaging
12	TLR1	rs5743621	G>A	P733L	0.995	P.D	0.00	Damaging
13	TLR1	rs41311402	A>G	L697S	1	P.D	0.00	Damaging
14	TLR1	rs56205407	A>G	I679T	0.999	P.D	0.00	Damaging
15	TLR1	rs117033348	A>G	L144P	1	P.D	0.04	Damaging
16	TLR2	rs5743706	T>A	Y715N	1	P.D	0.01	Damaging
17	TLR2	rs56303479	T>C	L81P	1	P.D	0.00	Damaging
18	TLR2	rs121917864	C>T	R677W	1	P.D	0.00	Damaging
19	TLR3	rs5743316	A>T	N284I	1	P.D	0.00	Damaging
20	TLR3	rs112666655	T>C	L545P	1	P.D	0.00	Damaging
21	TLR3	rs111488413	C>A	P880Q	1	P.D	0.00	Damaging
22	TLR4	rs77214890	G>T	D181Y	1	P.D	0.00	Damaging
23	TLR4	rs80197996	G>T	L470F	1	P.D	0.03	Damaging
24	TLR4	rs55905951	C>G	A676G	1	P.D	0.00	Damaging
25	TLR4	rs55786277	C>T	R804W	0.999	P.D	0.01	Damaging
26	TLR5	rs5744176	T>C	D694G	1	P.D	0.01	Damaging
27	TLR5	rs78098893	T>C	R752G	0.997	P.D	0.01	Damaging
28	TLR6	rs13102250	A>C	L105W	1	P.D	0.01	Damaging
29	TLR9	rs55881257	G>A	R962C	1	P.D	0.01	Damaging

Abbreviations: P.D; probablydamaging