Table 6.
Summary results of nsSNPs analysis by I-mutant and ConSurf.
|
|
I-mutant
|
ConSurf
|
|||||
|---|---|---|---|---|---|---|---|
|
Gene
Symbol |
SNP |
AA
substitution |
DDG ( Kcal/mol) | Stability | conservation scale | Functional or structural residue | |
| 1 | CHUK | rs56948661 | P623L | -0.97 | Decrease | 9 | F |
| 2 | CHUK | rs61732515 | Q277H | -1.58 | Decrease | 7 | - |
| 3 | CHUK | rs112432667 | E492G | -1.06 | Decrease | 4 | - |
| 4 | FOS | rs74685695 | V77G | -5.25 | Decrease | 9 | S |
| 5 | IRF5 | rs112815033 | L450P | -1.74 | Decrease | 8 | - |
| 6 | IRAK4 | rs55944915 | R391H | -1.32 | Decrease | 8 | F |
| 7 | IRAK4 | rs114820168 | R391C | -0.86 | Decrease | 8 | F |
| 8 | MAP3K7 | rs77759048 | W55R | -1.71 | Decrease | 8 | - |
| 9 | TBK1 | rs34774243 | K291E | -0.82 | Decrease | 6 | - |
| 10 | TBK1 | rs55824172 | S151F | 0.01 | Increase | 9 | F |
| 11 | TIRAP | rs74937157 | C134R | -1.55 | Decrease | 8 | - |
| 12 | TLR1 | rs5743621 | P733L | -1.33 | Decrease | 8 | F |
| 13 | TLR1 | rs41311402 | L697S | -1.51 | Decrease | 9 | S |
| 14 | TLR1 | rs56205407 | I679T | -1.91 | Decrease | 8 | - |
| 15 | TLR1 | rs117033348 | L144P | -0.79 | Decrease | 9 | S |
| 16 | TLR2 | rs5743706 | Y715N | -1.65 | Decrease | 9 | S |
| 17 | TLR2 | rs56303479 | L81P | -1.24 | Decrease | 9 | S |
| 18 | TLR2 | rs121917864 | R677W | -0.83 | Decrease | 9 | F |
| 19 | TLR3 | rs5743316 | N284I | 1.23 | Increase | 9 | F |
| 20 | TLR3 | rs112666655 | L545P | -1.10 | Decrease | 7 | - |
| 21 | TLR3 | rs111488413 | P880Q | -1.26 | Decrease | 9 | F |
| 22 | TLR4 | rs77214890 | D181Y | -0.98 | Decrease | 8 | F |
| 23 | TLR4 | rs80197996 | L470F | -0.86 | Decrease | 9 | S |
| 24 | TLR4 | rs55905951 | A676G | -1.19 | Decrease | 9 | S |
| 25 | TLR4 | rs55786277 | R804W | -0.54 | Decrease | 6 | - |
| 26 | TLR5 | rs5744176 | D694G | -1.31 | Decrease | 9 | F |
| 27 | TLR5 | rs78098893 | R752G | -1.49 | Decrease | 7 | - |
| 28 | TLR6 | rs13102250 | L105W | 0.91 | Increase | 9 | S |
| 29 | TLR9 | rs55881257 | R962C | -2.62 | Decrease | 8 | F |
Abbreviations: DDG; free energy change value (DDG<0: Decrease Stability, DDG>0: Increase Stability). The pH and the temperature were set to7 and 25˚C for all submissions, respectively. F: functional residue; S: structural residue.