Supplementary Table 1.

Surface accessibility of wild-type and mutant variants in TLRs network intermediate molecules.

	Gene Symbol	SNP	AA substitution	Class assignment	AA	AA position	RSA	ASA	Z-fit score
1	CHUK	rs56948661	P623L	Exposed Exposed	P L	623 623	0.544 0.537	77.179 98.306	1.190 1.088
2	FOS	rs74685695	V77G	Buried Buried	V G	77 77	0.082 0.159	12.58 12.55	-0.799 -0.920
3	IRAK4	rs55944915	R391H	Exposed Exposed	R H	391 391	0.500 0.520	114.40 94.58	-0.611 -0.727
4	IRAK4	rs114820168	R391C	Exposed Exposed	R C	391 391	0.500 0.477	114.40 67.04	-0.611 -0.891
5	TBK1	rs55824172	S151F	Buried Buried	S F	151 151	0.132 0.116	15.52 23.30	0.068 -0.048
6	TLR1	rs5743621	P733L	Exposed Exposed	P L	733 733	0.575 0.569	81.57 104.23	0.687 0.717
7	TLR1	rs41311402	L697S	Buried Buried	L S	697 697	0.028 0.030	5.05 3.49	0.951 0.649
8	TLR1	rs117033348	L144P	Buried Buried	L P	144 144	0.038 0.035	6.92 5.023	0.503 0.657
9	TLR2	rs5743706	Y715N	Buried Buried	Y N	715 715	0.152 0.153	32.46 22.39	0.193 0.253
10	TLR2	rs56303479	L81P	Buried Buried	L P	81 81	0.038 0.029	6.93 4.10	0.362 0.758
11	TLR2	rs121917864	R677W	Buried Buried	R W	677 677	0.243 0.255	55.60 61.32	-0.079 -0.088
12	TLR3	rs5743316	N284I	Buried Buried	N I	284 284	0.083 0.088	12.16 16.33	-1.686 -1.081
13	TLR3	rs111488413	P880Q	Exposed Exposed	P Q	880 880	0.401 0.446	56.88 79.65	0.150 0.108
14	TLR4	rs77214890	D181Y	Buried Buried	D Y	181 181	0.240 0.258	34.52 55.24	0.528 0.277
15	TLR4	rs80197996	L470F	Buried Buried	L F	470 470	0.090 0.089	16.40 17.88	0.080 0.247
16	TLR4	rs55905951	A676G	Buried Buried	A G	676 676	0.033 0.034	3.62 2.71	-0.046 -0.158
17	TLR5	rs5744176	D694G	Buried Buried	D G	694 694	0.164 0.173	23.57 13.64	-0.270 -0.384
18	TLR6	rs13102250	L105W	Buried Buried	L W	105 105	0.030 0.031	5.51 7.40	0.843 0.799
19	TLR9	rs55881257	R962C	ExposedExposed	R C	962 962	0.419 0.464	95.95 65.20	0.066 0.045

Abbreviations: RSA: Relative Surface Accessibility; ASA: Absolute Surface Accessibility. Values for wild type and mutant variants are presented by red and green color respectively