Table 2.

Clinical Changes in Patients with OCD Receiving Lamotrigine versus Placebo at Baseline and Week 12 (LOCF)

	Lamotrigine		Placebo		Mann- Whitney p
	Baseline	Week12†	Baseline	Week12 ‡	Baseline	Week12
YBOCS
Obsession Mean±SD	13.17±2.2	9±3.6	13.9±2.2	11.3 ±3.1	0.202	0.019
Compulsion Mean±SD	13.60±2.7	9.31±3.5	14.7±2.5	12.19 ±3.4	0.103	0.005
Total score Mean± SD	26.83±4.0	18.31±6.6	28.60±3.8	23.48 ±5.8	0.108	0.007

^†Observed cases (Lamotrigine group n = 26) Wilcoxon Signed Ranks Test Z = −4.29/ p ≤ 0.0001, Z = −4.05 p ≤ 0.0001, Z= −2.38/p ≤ 0.0001.

^‡Observed cases (Placebo group n = 27) Wilcoxon Signed Ranks Test Z = −3.69/ p ≤ 0.0001, Z = −3.72 p ≤ 0.0001, Z = −4.20/ p ≤0.0001.