Figure 1.

Reduction of GluA1 phosphorylation in the cGKII KO amygdala and impaired cued fear conditioning. (A) Representative immunoblots and quantitative analysis of whole amygdala lysates from the WT and KO animals showing significant reduction of GluA1-pS845 in the KO amygdala (n = 4 experiments, (*) P < 0.05, unpaired two-tailed student's t-test). (B) Diagram of auditory cued fear-conditioning protocol and summary of average percentage freezing during the 30 sec prior to the initial tone as well as the average freezing during each of the two tones for each genotype showing reduced freezing levels for KO mice during presentation of auditory cue (n = 20 WT and 21 KO mice, (*) P < 0.05, unpaired two-tailed Student's t-test).