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. 2016 Aug;23(8):435–441. doi: 10.1101/lm.042960.116

Figure 3.

Figure 3.

Reduction of AMPAR levels in the NAc of KO animals and KO-mediated antidepressant effects. (A) Representative immunoblots and quantitative analysis of PSD from the NAc of the WT and KO animals showing significant reduction of GluA1, GluA1-pS845, and GluA2/3 in the KO NAc (n = 7 experiments, (****) P < 0.0001, unpaired two-tailed Student's t-test). (B) Percentage of sucrose water consumed out of total liquid consumption overnight for both WT and KO mice during the sucrose preference test showing significant increase of sucrose consumption for the KO mice (n = 15 WT and 15 KO mice, (*) P < 0.05, unpaired two-tailed Student's t-test). (C) Average of the total time WT and KO mice spent immobile during the 6-min tail suspension test showing significant reduction in immobility for KO mice (n = 16 WT and 16 KO mice, (*) P < 0.05 and (**) P < 0.01, unpaired two-tailed Student's t-test).