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. 2016 Jul 16;14:38. doi: 10.1186/s12958-016-0173-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — In a normal cycle, only the dominant follicle responds to LH when it reaches 10 mm diameter. In PCOS the response to LH occurs inappropriately in smaller follicles and many antral follicles reach terminal differentiation before time, producing a greater quantity of steroids and inhibin B that exert negative feedback on FSH production