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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Curr Opin Genet Dev. 2015 Sep 4;35:16–24. doi: 10.1016/j.gde.2015.08.004

Figure 3.

Figure 3

Recent applications of statistical linking methods to identify and treat human disease. A. Cha et al. 2012 used overlap between vasculature genes and genes linked to antifungal sensitivity in yeast to identify TBZ as a novel vascular disrupting agent. TBZ disassembled vasculature in Xenopus embryos (top panels) and slowed human fibrosarcoma tumor growth in mice (bottom panels). Adapted from Cha et al. 2012 [84]. B. Tardiff et al. 2013 overexpressed α-synuclein and screened for phenotype rescuing compounds. One such compound, NAB, in turn ameliorated neuronal proteinopathies in worm neurons. Adapted from Tardiff et al. 2013 [88]. C. Chan et al. 2014 identified divergent phenotypes in planarians and schistosomes in response to the small molecule PZQ. Cav, voltage-gated calcium channel; Nav, voltage-gated sodium channel; HVA, high-voltage activated; LVA, low-voltage activated. Adapted from Chan et al. 2014 [90].