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. Author manuscript; available in PMC: 2017 Jan 7.
Published in final edited form as: Nature. 2016 Jul 7;535(7610):169–172. doi: 10.1038/nature18615

Figure 4. Inhibitor binding site.

Figure 4

a, Details of the inhibitor biding site in the apo GP. The backbone is shown as ribbons with GP1 in blue and GP2 in red, side-chains as grey sticks. b, Tunnels of the GP trimer viewed along the 3-fold axis towards the viral membrane. Toremifenes bound at the entrances of the tunnels are shown as yellow sticks. c, Details of protein-inhibitor interactions of the GP-toremifene complex, and d, GP-ibuprofen complex. Toremifen is shown as yellow sticks, ibuprofen as cyan sticks. Protein main-chains are shown as ribbons and side-chains as sticks (GP1 blue, GP2 red). Side-chains in the apo structure with large conformational changes are shown as thinner grey sticks.