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. Author manuscript; available in PMC: 2017 Jul 15.
Published in final edited form as: Clin Cancer Res. 2016 Mar 2;22(14):3513–3523. doi: 10.1158/1078-0432.CCR-15-2308

Figure 1. Qualitative analysis identified four differentially regulated metabolites (DRMs) in GBM.

Figure 1

LC-MS/MS analysis was used to generate the intracellular compartment and extracellular milieumetabolomic profiles for commercially available and patient-derived GBM cell lines and NHAs. This data has been presented as heat maps, the identified DRMs are marked by red boxes, while the NHAs are marked by green boxes.

[A] The heat map of the intracellular compartment and extracellular milieu of the GBM cell lines and NHAs analyzed.

[B] In the intracellular compartment, four metabolites were discovered as upregulated DRMs: tryptophan, kynurenine, methionine, and MTA.

[C] In the extracellular milieu, two metabolites were discovered as DRMs: kynurenine and MTA.