Table 1.
| a – Characteristics of Participants, by Quartile of Estradiol Level (n=1,338) | ||||
|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | |
| Age (mean ± SD) | 61.8 ± 4.7 | 61.9 ± 4.6 | 61.6 ± 5.0 | 61.0 ± 5.2 |
| Age at menopause (mean ± SD) | 47.9 ± 5.4 | 48.2 ± 5.8 | 48.1 ± 5.8 | 48.9 ± 5.1 |
| Education (n, %)1 | ||||
| RN | 138 (73.4%) | 150 (73.2%) | 142 (77.6%) | 130 (76.9%) |
| Bachelor’s | 36 (19.2%) | 40 (19.5%) | 25 (13.7%) | 30 (17.8%) |
| Graduate | 14 (7.5%) | 15 (7.3%) | 16 (8.7%) | 9 (5.3%) |
| Smoking (n, %) | ||||
| Never | 152 (45.5%) | 161 (48.4%) | 164 (48.8%) | 153 (45.7%) |
| Former | 137 (41.0%) | 148 (44.4%) | 135 (40.2%) | 147 (43.9%) |
| Current | 45 (13.5%) | 24 (7.2%) | 37 (11.0%) | 35 (10.5%) |
| Body mass index (n, %) | 23.4 ± 3.3 | 24.4 ± 3.1 | 26.3 ± 4.2 | 29.2 ± 5.2 |
| Alcohol (n, %) | ||||
| Non-drinker | 123 (36.8%) | 123 (36.9%) | 141 (42.0%) | 173 (51.6%) |
| 1–14 g/day | 182 (54.5%) | 179 (53.8%) | 159 (47.3%) | 131 (39.1%) |
| ≥15 g/day | 29 (8.7%) | 31 (9.3%) | 36 (10.7%) | 31 (9.3%) |
| Physical activity, MET-hr/week (mean ± SD) | 18.2 ± 21.1 | 19.1 ± 21.5 | 17.5 ± 21.8 | 14.1 ± 17.6 |
| Diabetes (n, %) | 5 (1.5%) | 8 (2.4%) | 16 (4.8%) | 21 (6.3%) |
| Hypertension (n, %) | 91 (27.3%) | 97 (29.1%) | 104 (31.0%) | 133 (39.7%) |
| Myocardial infarction (n, %) | 10 (3.0%) | 8 (2.4%) | 11 (3.3%) | 9 (2.7%) |
| SF-36 Mental Health Index (mean ± SD)2,3 | 82.2 ± 12.5 | 83.9 ± 10.9 | 80.9 ± 11.8 | 82.3 ± 10.5 |
| Current antidepressant use (n, %)2 | 10 (5.3%) | 4 (2.0%) | 13 (7.1%) | 10 (5.9%) |
| b – Characteristics of Participants, by Quartile of Testosterone Level (n=2,569) | ||||
|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | |
| Age (mean ± SD) | 60.6 ± 5.3 | 60.0 ± 5.3 | 60.3 ± 5.5 | 60.4 ± 5.8 |
| Age at menopause (mean ± SD) | 46.6 ± 6.4 | 47.3 ± 6.2 | 47.8 ± 5.7 | 47.9 ± 5.8 |
| Education (n, %)1 | ||||
| RN | 231 (77.5%) | 196 (72.9%) | 216 (75.0%) | 224 (75.4%) |
| Bachelor’s | 46 (15.4%) | 53 (19.7%) | 51 (17.7%) | 52 (17.5%) |
| Graduate | 21 (7.1%) | 20 (7.4%) | 21 (7.3%) | 21 (7.1%) |
| Smoking (n, %) | ||||
| Never | 303 (47.3%) | 311 (48.2%) | 312 (48.8%) | 295 (45.9%) |
| Former | 288 (44.9%) | 275 (42.6%) | 262 (40.9%) | 267 (41.5%) |
| Current | 50 (7.8%) | 59 (9.2%) | 66 (10.3%) | 81 (12.6%) |
| Body mass index (n, %) | 25.3 ± 4.4 | 25.4 ± 4.3 | 25.4 ± 4.3 | 25.2 ± 4.6 |
| Alcohol (n, %) | ||||
| Non-drinker | 237 (37.0%) | 267 (41.4%) | 268 (41.9%) | 264 (41.1%) |
| 1–14 g/day | 348 (54.3%) | 324 (50.2%) | 309 (48.3%) | 311 (48.4%) |
| ≥15 g/day | 56 (8.7%) | 54 (8.4%) | 63 (9.8%) | 68 (10.6%) |
| Physical activity, MET-hr/week (mean ± SD) | 17.1 ± 20.0 | 18.0 ± 30.9 | 18.1 ± 20.6 | 17.9 ± 30.5 |
| Diabetes (n, %) | 21 (3.3%) | 17 (2.6%) | 26 (4.1%) | 21 (3.3%) |
| Hypertension (n, %) | 206 (32.1%) | 173 (26.8%) | 189 (29.5%) | 192 (29.9%) |
| Myocardial infarction (n, %) | 22 (3.4%) | 19 (3.0%) | 19 (3.0%) | 11 (1.7%) |
| SF-36 Mental Health Index (mean ± SD)2,3 | 81.2 ± 12.3 | 82.1 ± 11.8 | 83.8 ± 11.5 | 81.0 ± 11.5 |
| Current antidepressant use (n, %)2 | 18 (6.0%) | 15 (5.6%) | 14 (4.9%) | 15 (5.1%) |
1
only available in the cognitive substudy
2
assessed at the most recent measurement prior to the first cognitive interview
3
range: 0–100 (lower scores indicate more depressive symptoms)
1
only available in the cognitive substudy
2
assessed at the most recent measurement prior to the first cognitive interview