Table 2.
Mean Differences in Overall Cognition, by Quartile of Plasma Hormone Level*
| Q1 (ref.) | Q2 vs Q1 | Q3 vs Q1 | Q4 vs Q1 | p trend | |
|---|---|---|---|---|---|
| Estrone (n=655) | |||||
| Model 1 | 0.00 | −0.01 (−0.15, 0.13) | 0.00 (−0.14, 0.14) | 0.10 (−0.04, 0.24) | 0.10 |
| Model 2 | 0.00 | −0.01 (−0.15, 0.13) | −0.04 (−0.18, 0.10) | 0.09 (−0.05, 0.24) | 0.18 |
| Estrone Sulfate (n=446) | |||||
| Model 1 | 0.00 | 0.13 (−0.04, 0.30) | 0.15 (−0.02, 0.32) | 0.08 (−0.08, 0.25) | 0.57 |
| Model 2 | 0.00 | 0.13 (−0.04, 0.29) | 0.12 (−0.05, 0.29) | 0.09 (−0.09, 0.26) | 0.56 |
| Estradiol (n=688) | |||||
| Model 1 | 0.00 | −0.05 (−0.19, 0.09) | −0.04 (−0.18, 0.10) | 0.01 (−0.13, 0.15) | 0.70 |
| Model 2 | 0.00 | −0.07 (−0.21, 0.07) | −0.03 (−0.17, 0.12) | −0.01 (−0.16, 0.14) | 0.85 |
| Androstenedione (n=400) | |||||
| Model 1 | 0.00 | 0.01 (−0.17, 0.19) | −0.03 (−0.21, 0.15) | −0.09 (−0.27, 0.09) | 0.26 |
| Model 2 | 0.00 | −0.04 (−0.23, 0.14) | −0.07 (−0.25, 0.11) | −0.14 (−0.32, 0.05) | 0.12 |
| Testosterone (n=1,063) | |||||
| Model 1 | 0.00 | 0.00 (−0.12, 0.11) | −0.02 (−0.13, 0.10) | 0.04 (−0.07, 0.16) | 0.45 |
| Model 2 | 0.00 | −0.01 (−0.12, 0.11) | −0.04 (−0.16, 0.07) | 0.02 (−0.09, 0.14) | 0.68 |
| DHEA (n=522) | |||||
| Model 1 | 0.00 | 0.02 (−0.14, 0.18) | 0.04 (−0.12, 0.20) | −0.04 (−0.20, 0.13) | 0.63 |
| Model 2 | 0.00 | 0.02 (−0.14, 0.18) | 0.03 (−0.13, 0.19) | −0.06 (−0.22, 0.10) | 0.44 |
| DHEA Sulfate (n=900) | |||||
| Model 1 | 0.00 | 0.13 (0.01−0.26) | 0.06 (−0.07, 0.18) | 0.03 (−0.10, 0.15) | 0.83 |
| Model 2 | 0.00 | 0.13 (0.01−0.25) | 0.05 (−0.07, 0.18) | 0.00 (−0.13, 0.13) | 0.51 |
*
values indicate standard units of averaged z-scores from each cognitive test
Model 1: adjusted for age, education
Model 2: adjusted for age, education, BMI, alcohol use, physical activity, age at menopause, depression status, antidepressant use