Table 4.
Odds of Subjective Cognitive Concerns, by Quartile of Plasma Hormone Level*
| Q1 (ref.) | Q2 vs Q1 | Q3 vs Q1 | Q4 vs Q1 | p trend | |
|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |||
| Estrone (n=949) | |||||
| Model 1 | 1.00 | 0.88 (0.60–1.28) | 1.03 (0.71–1.51) | 0.78 (0.54–1.14) | 0.27 |
| Model 2 | 1.00 | 0.86 (0.58–1.27) | 1.09 (0.74–1.63) | 0.81 (0.54–1.21) | 0.42 |
| Estrone Sulfate (n=701) | |||||
| Model 1 | 1.00 | 1.04 (0.67–1.62) | 0.99 (0.64–1.54) | 0.65 (0.42–1.01) | 0.03 |
| Model 2 | 1.00 | 1.11 (0.71–1.76) | 1.05 (0.67–1.67) | 0.75 (0.47–1.19) | 0.13 |
| Estradiol (n=1,008) | |||||
| Model 1 | 1.00 | 0.91 (0.63–1.31) | 1.03 (0.71–1.49) | 0.84 (0.58–1.21) | 0.39 |
| Model 2 | 1.00 | 0.91 (0.62–1.33) | 0.98 (0.66–1.45) | 0.85 (0.55–1.30) | 0.49 |
| Androstenedione (n=655) | |||||
| Model 1 | 1.00 | 0.63 (0.40–0.99) | 0.71 (0.45–1.12) | 0.86 (0.54–1.37) | 0.82 |
| Model 2 | 1.00 | 0.70 (0.43–1.13) | 0.72 (0.45-1.16) | 0.95 (0.59-1.55) | 0.95 |
| Testosterone (n=2,053) | |||||
| Model 1 | 1.00 | 1.07 (0.83–1.39) | 0.92 (0.72–1.19) | 1.07 (0.83–1.39) | 0.75 |
| Model 2 | 1.00 | 1.06 (0.81–1.38) | 0.91 (0.70–1.18) | 1.06 (0.82–1.39) | 0.80 |
| DHEA (n=966) | |||||
| Model 1 | 1.00 | 1.32 (0.91–1.91) | 1.52 (1.05–2.20) | 1.50 (1.03–2.18) | 0.05 |
| Model 2 | 1.00 | 1.32 (0.90–1.93) | 1.57 (1.07–2.30) | 1.55 (1.05–2.28) | 0.03 |
| DHEA Sulfate (n=1,795) | |||||
| Model 1 | 1.00 | 1.12 (0.85–1.47) | 1.04 (0.79–1.36) | 1.30 (0.98–1.72) | 0.09 |
| Model 2 | 1.00 | 1.12 (0.85–1.48) | 1.03 (0.77–1.36) | 1.38 (1.03–1.84) | 0.04 |
Model 1: adjusted for age, occupation
Model 2: adjusted for age, occupation, BMI, alcohol use, physical activity, age at menopause, depression status, antidepressant use
*
Odds of any versus no SCC across 6 questionnaire items regarding self-perceived cognitive status