Table 3. Parameters resulting from linear mixed effects regression models.
Variable | Learning | Delayed Recall | Executive Functioning | ||||||
---|---|---|---|---|---|---|---|---|---|
Primary Model | B (SE) | p | 95% CI | B (SE) | p | 95% CI | B (SE) | p | 95% CI |
Intercept | -3.49 (.54) | <.001* | -4.56, -2.43 | -3.24 (.55) | <.001* | -4.33, -2.16 | -1.70 (.58) | .004* | -2.85, -0.55 |
Sex (Female) | 0.55 (.10) | <.001* | 0.35, 0.74 | 0.48 (.10) | <.001* | 0.28, 0.68 | 0.03 (.11) | .75 | -0.18, 0.25 |
WRAT-III raw score | 0.06 (.01) | <.001* | 0.04, 0.08 | 0.06 (.01) | <.001* | 0.04, 0.08 | 0.04 (.11) | .001* | 0.02, 0.06 |
Interval (years) | -0.02 (.03) | .66 | -0.08, 0.05 | -0.04 (.03) | .24 | -0.11, 0.03 | -0.01 (.04) | .85 | -0.08, 0.07 |
Time (age centered) | -0.02 (.01) | .001* | -0.03, -0.01 | -0.02 (.01) | .01* | -0.03, -0.004 | -0.04 (.01) | <.001* | -0.05, -0.02 |
PiB DVR | 0.45 (.44) | .31 | -0.42, 1.32 | 0.76 (.43) | .08 | -0.09, 1.60 | 0.27 (.44) | .53 | -0.59, 1.13 |
Time × PiB DVR | -0.08 (.04) | .051 | -0.16, 0.00 | -0.14 (.04) | .002* | -0.23, -0.05 | -0.09 (.04) | .016* | -0.16, -0.02 |
Secondary Model | |||||||||
Intercept | -3.80 (.55) | <.001* | -4.89, -2.72 | -3.58 (.55) | <.001* | -4.67, -2.49 | -1.83 (.60) | .003 | -3.01, -0.65 |
Sex (Female) | 0.58 (.10) | <.001* | 0.38, 0.77 | 0.51 (.10) | <.001* | 0.31, 0.71 | 0.04 (.11) | .68 | -0.17, 0.26 |
WRAT-III raw score | 0.07 (.01) | <.001* | 0.05, 0.09 | 0.07 (.01) | <.001* | 0.05, 0.09 | 0.04 (.01) | .001* | 0.02, 0.06 |
Interval (years) | -0.01 (.03) | .70 | -0.08, 0.05 | -0.04 (.03) | .20 | -0.11, 0.02 | -0.01 (.04) | .82 | -0.08, 0.06 |
APOE | 0.10 (.12) | .40 | -0.14, 0.34 | 0.04 (.12) | .76 | -0.19, 0.26 | 0.08 (.13) | .52 | -0.17, 0.33 |
Time (age centered) | -0.02 (.01) | .02 | -0.03, -0.002 | -0.02 (.01) | .07 | -0.03, 0.001 | -0.03 (.01) | <.001* | -0.04, -0.02 |
PiB DVR | -0.59 (.71) | .41 | -1.97, 0.80 | -0.77 (.68) | .25 | -2.13, 0.56 | -0.93 (.69) | .18 | -2.29, 0.43 |
Time × PiB DVR | 0.03 (.06) | .56 | -0.08, 0.14 | 0.05 (.06) | .45 | -0.07, 0.17 | 0.003 (.05) | .95 | -0.10, 0.10 |
Time × APOE | 0.01 (.01) | .69 | -0.02, 0.03 | 0.01 (.01) | .35 | -0.01, 0.04 | -0.01 (.01) | .52 | -0.03, 0.02 |
APOE × PiB DVR | 1.82 (.90) | .04 | 0.05, 3.60 | 2.80 (.87) | .001* | 1.09, 4.50 | 2.01 (.89) | .02 | 0.27, 3.75 |
Time × APOE × PiB DVR | -0.27 (.08) | .002* | -0.43, -0.10 | -0.41 (.09) | <.001* | -0.59, -0.24 | -0.18 (.07) | .02 | -0.32, -0.03 |
WRAT-III = Wide Range Achievement Test – 3rd Edition reading subtest. Interval = Years between Wave 2 neuropsychological evaluation and PET scan. Time = age centered by mean age of sample at baseline neuropsychological evaluation (54.33). PiB DVR = [C-11]Pittsburgh compound B Distribution Volume Ratio centered by mean DVR value of sample (1.17). Outcome measures of delayed recall, learning, and executive functioning were standardized to z-scores prior to inclusion in models.
Statistically significant using Bonferroni adjusted p-value (< .017)