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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Alzheimers Dement. 2016 Jan 21;12(7):805–814. doi: 10.1016/j.jalz.2015.12.009

Table 3. Parameters resulting from linear mixed effects regression models.

Variable Learning Delayed Recall Executive Functioning
Primary Model B (SE) p 95% CI B (SE) p 95% CI B (SE) p 95% CI
Intercept -3.49 (.54) <.001* -4.56, -2.43 -3.24 (.55) <.001* -4.33, -2.16 -1.70 (.58) .004* -2.85, -0.55
Sex (Female) 0.55 (.10) <.001* 0.35, 0.74 0.48 (.10) <.001* 0.28, 0.68 0.03 (.11) .75 -0.18, 0.25
WRAT-III raw score 0.06 (.01) <.001* 0.04, 0.08 0.06 (.01) <.001* 0.04, 0.08 0.04 (.11) .001* 0.02, 0.06
Interval (years) -0.02 (.03) .66 -0.08, 0.05 -0.04 (.03) .24 -0.11, 0.03 -0.01 (.04) .85 -0.08, 0.07
Time (age centered) -0.02 (.01) .001* -0.03, -0.01 -0.02 (.01) .01* -0.03, -0.004 -0.04 (.01) <.001* -0.05, -0.02
PiB DVR 0.45 (.44) .31 -0.42, 1.32 0.76 (.43) .08 -0.09, 1.60 0.27 (.44) .53 -0.59, 1.13
Time × PiB DVR -0.08 (.04) .051 -0.16, 0.00 -0.14 (.04) .002* -0.23, -0.05 -0.09 (.04) .016* -0.16, -0.02
Secondary Model
Intercept -3.80 (.55) <.001* -4.89, -2.72 -3.58 (.55) <.001* -4.67, -2.49 -1.83 (.60) .003 -3.01, -0.65
Sex (Female) 0.58 (.10) <.001* 0.38, 0.77 0.51 (.10) <.001* 0.31, 0.71 0.04 (.11) .68 -0.17, 0.26
WRAT-III raw score 0.07 (.01) <.001* 0.05, 0.09 0.07 (.01) <.001* 0.05, 0.09 0.04 (.01) .001* 0.02, 0.06
Interval (years) -0.01 (.03) .70 -0.08, 0.05 -0.04 (.03) .20 -0.11, 0.02 -0.01 (.04) .82 -0.08, 0.06
APOE 0.10 (.12) .40 -0.14, 0.34 0.04 (.12) .76 -0.19, 0.26 0.08 (.13) .52 -0.17, 0.33
Time (age centered) -0.02 (.01) .02 -0.03, -0.002 -0.02 (.01) .07 -0.03, 0.001 -0.03 (.01) <.001* -0.04, -0.02
PiB DVR -0.59 (.71) .41 -1.97, 0.80 -0.77 (.68) .25 -2.13, 0.56 -0.93 (.69) .18 -2.29, 0.43
Time × PiB DVR 0.03 (.06) .56 -0.08, 0.14 0.05 (.06) .45 -0.07, 0.17 0.003 (.05) .95 -0.10, 0.10
Time × APOE 0.01 (.01) .69 -0.02, 0.03 0.01 (.01) .35 -0.01, 0.04 -0.01 (.01) .52 -0.03, 0.02
APOE × PiB DVR 1.82 (.90) .04 0.05, 3.60 2.80 (.87) .001* 1.09, 4.50 2.01 (.89) .02 0.27, 3.75
Time × APOE × PiB DVR -0.27 (.08) .002* -0.43, -0.10 -0.41 (.09) <.001* -0.59, -0.24 -0.18 (.07) .02 -0.32, -0.03

WRAT-III = Wide Range Achievement Test – 3rd Edition reading subtest. Interval = Years between Wave 2 neuropsychological evaluation and PET scan. Time = age centered by mean age of sample at baseline neuropsychological evaluation (54.33). PiB DVR = [C-11]Pittsburgh compound B Distribution Volume Ratio centered by mean DVR value of sample (1.17). Outcome measures of delayed recall, learning, and executive functioning were standardized to z-scores prior to inclusion in models.

*

Statistically significant using Bonferroni adjusted p-value (< .017)