Table 3.
Levels of Aβ and apoE in temporal cortex from AD subjects with or without CAA
| Without CAA (N=39) | With CAA (N=60) | |
|---|---|---|
| Sex; Male | 17 (44) | 32 (53) |
| APOE4+ | 21 (54) | 42 (70) |
| Age; years | 80 (76, 85) | 80 (75, 85) |
| Braak Stage | ||
| <5 | 4 (10) | 3 (5) |
| 5-5.5 | 14 (36) | 24 (40) |
| 6 | 21 (54) | 33 (55) |
| Thal phase | ||
| <4 | 2 (5) | 4 (7) |
| 4 | 3 (8) | 7 (12) |
| 5 | 34 (87) | 49 (82) |
|
| ||
| Aβ40 (ng/mg protein) | ||
| TBS | 0.26 (0.03) | 1.43 (0.19) |
| TX | 0.25 (0.03) | 1.15 (0.14) |
| GuHCl | 35.1 (9.8) | 708.0 (108.4) |
| Aβ42 (ng/mg protein) | ||
| TBS | 0.46 (0.11) | 0.58 (0.07) |
| TX | 5.16 (0.55) | 3.92 (0.27) |
| GuHCl | 687.6 (57.3) | 839.3 (65.7) |
| Aβ40/Aβ42 | ||
| TBS | 2.65 (1.01) | 3.89 (0.83) |
| TX | 0.09 (0.03) | 0.35 (0.05) |
| GuHCl | 0.06 (0.02) | 0.74 (0.09) |
| ApoE (ng/mg protein) | ||
| TBS | 1.27 (0.08) | 1.37 (0.07) |
| TX | 1.59 (0.08) | 1.74 (0.11) |
| GuHCl | 381.4 (78.2) | 585.3 (59.0) |
Median and interquartile range (IQR) shown for age; number (%) shown for gender, APOE4+, Braak stage and, Thal phase; Mean (SEM) shown for Aβ and apoE levels.