. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: Acta Neuropathol. 2016 May 14;132(2):225–234. doi: 10.1007/s00401-016-1580-y

Table 4.

Associations of CAA, sex, and APOE4 with levels of Aβ and apoE in temporal cortex

	TBS		TX		GuHCl
	Relative Level ^a (95% CI)	p-value ^b	Relative Level ^a (95% CI)	p-value ^b	Relative Level ^a (95% CI)	p-value ^b
Aβ40
CAA+	3.50 (2.45, 5.00)	<.001	3.64 (2.37, 5.59)	<.001	17.55 (10.17, 30.29)	<.001
Sex; Male	0.71 (0.50, 1.00)	0.053	0.77 (0.51, 1.16)	0.213	0.68 (0.40, 1.17)	0.161
APOE4+	1.71 (1.20, 2.46)	0.003	1.61 (1.06, 2.47)	0.027	3.99 (2.30, 6.92)	<.001

Aβ42
CAA+	0.88 (0.67, 1.17)	0.377	1.74 (0.99, 3.07)	0.053	1.22 (0.98, 1.51)	0.077
Sex; Male	1.10 (0.83, 1.45)	0.513	0.99 (0.57, 1.73)	0.978	1.15 (0.93, 1.42)	0.208
APOE4+	0.92 (0.69, 1.22)	0.575	1.26 (0.72, 2.22)	0.423	1.10 (0.88, 1.37)	0.387

Aβ40/Aβ42
CAA+	3.97 (2.67, 5.92)	<.001	2.30 (1.43, 3.69)	<.001	14.43 (8.74, 23.83)	<.001
Sex; Male	0.64 (0.43, 0.96)	0.029	0.91 (0.57, 1.44)	0.676	0.59 (0.36, 0.97)	0.038
APOE4+	1.86 (1.24, 2.78)	0.003	1.13 (0.70, 1.81)	0.624	3.62 (2.18, 6.01)	<.001

ApoE
CAA+	1.08 (0.94, 1.25)	0.275	1.07 (0.92, 1.24)	0.409	1.69 (1.15, 2.48)	0.007
Sex; Male	1.09 (0.95, 1.26)	0.231	1.15 (0.99, 1.34)	0.068	0.74 (0.51, 1.08)	0.119
APOE4+	0.80 (0.69, 0.93)	0.003	0.96 (0.83, 1.13)	0.649	1.69 (1.15, 2.49)	0.008

Analyses use logarithm of biochemical measures as response variable in linear regression analyses including variables CAA group (severe versus none), sex (male vs. female) and APOE4 (presence vs. absence) and also adjusting for age; estimated effects are exponentiated to provide effect expressed as a relative level or fold change.

Wald p-value.