Table 1.

Studies reporting DNA damage in major psychiatric disorders.

Psychiatric disorder	Biomarkers	Source	References
Major Depressive Disorder	8-oxodG increase	Serum	Forlenza & Miller 2006, Maes et al. 2009
		Leukocytes	Irie et al. 2003
	mtDNA damage	Leukocytes	Chang et al. 2015
	ss & dsDNA breaks	Leukocytes	Czarny et al. 2015
	Telomere shortening	Leukocytes	Simon et al. 2006
Bipolar Disorder	8-oxodG increases	Serum	Soeiro-de-Souza et al. 2013
	8-oxodG and 8-oxoGuo increases	Urine	Munkholm et al. 2015
	More DNA fragmentation	Brain tissue	Buttner et al. 2007
	ss & dsDNA breaks	Brain tissue	Mustak et al. 2010
	RNA damage	Brain tissue	Che et al. 2010
	mtDNA copy number decrease and damage	Leukocytes	Chang et al. 2014
	Telomere shortening		Simon et al. 2006
Schizophrenia	8-oxodG increase	Serum	Sertan Co-poglu et al. 2015
	8-oxodG and 8-oxoGuo increase	Urine	Jorgensen et al. 2013
	8-oxodG increase	Brain tissue	Cardozo-Pelaez et al. 2000. Nishioka & Arnold 2004, Che et al. 2010
	ss & dsDNA breaks	Leukocytes	Muraleedharan et al. 2015

ss & dsDNA: single strand &double strand DNA; mtDNA: mitochondrial DNA; 8-oxodG: 8-oxo-7, 8-dihydro-2-dihydroguanonine; 8-oxi-Guo: 8-oxo-7,8-dihydroguanonine.