Gene expression levels of multiple immune stimulatory molecules including CD80, CD86, OX40L, 4-1BB, ICOS, CD127 were analyzed in “mesenchymal” lung adenocarcinoma versus “epithelial” lung adenocarcinoma in tumor tissues from (A) TCGA, (B) PROSPECT. Gene expression of IFN-γ and IFN-γ inducible genes including CXCL10 and IDO were also analyzed in “mesenchymal” in comparison to “epithelial” lung adenocarcinoma in tumor tissues from (C) TCGA, (D) PROSPECT.