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AngII potentiates IL-1β-induced NOX-1 expression in VSMC through HuR-dependent NOX-1 mRNA stability. (A) Effects of MS-444 and HuR siRNA on NOX-1 mRNA levels in VSMC stimulated with AngII+IL-1β for 24 h. (B) NOX-1 mRNA binding to HuR by ribonucleoprotein immunoprecipitation in VSMC stimulated with AngII+IL-1β for 24 h. Data are expressed as mean±SEM. *P<0.05, **P<0.01 vs Control; ††P<0.01 vs AngII+IL-1β. n=4–7.
