TABLE 2.
Ambulatory blood pressure results by treatment group and pool
Variable | Normoglycemic subgroup | Prediabetes mellitus subgroup | T2DM subgroup | |||||||||
Pool A SBP | Placebo | AZL-M 40 mg | AZL-M 80 mg | OLM 40 mg | Placebo | AZL-M 40 mg | AZL-M 80 mg | OLM 40 mg | Placebo | AZL-M 40 mg | AZL-M 80 mg | OLM 40 mg |
Baseline (mmHg) | 146 | 146 | 145 | 146 | 145 | 145 | 146 | 146 | 147 | 144 | 146 | 144 |
Δ (mmHg) | −0.8 ± 1.1 | −15.1 ± 0.9* | −14.2 ± 0.8* | −13.2 ± 0.8* | −1.8 ± 1.0 | −13.4 ± 0.8* | −16.8 ± 0.8*,§ | −12.9 ± 0.7* | 0.5 ± 1.7 | −12.1 ± 1.0* | −12.3 ± 1.1* | −9.8 ± 1.2* |
Pool A DBP | Placebo | AZL-M 40 mg | AZL-M 80 mg | OLM 40 mg | Placebo | AZL-M 40 mg | AZL-M 80 mg | OLM 40 mg | Placebo | AZL-M 40 mg | AZL-M 80 mg | OLM 40 mg |
Baseline (mmHg) | 90 | 90 | 89 | 89 | 86 | 87 | 88 | 88 | 89 | 85 | 86 | 84 |
Δ (mmHg) | −0.1 ± 0.7 | −9.7 ± 0.6* | −8.6 ± 0.5* | −8.5 ± 0.5* | −1.1 ± 0.7 | −8.2 ± 0.5* | −10.5 ± 0.5*,§ | −7.9 ± 0.5* | +0.7 ± 1.1 | −7.1 ± 0.7* | −7.3 ± 0.7* | −5.4 ± 0.7* |
N | 100 | 173 | 200 | 203 | 114 | 200 | 184 | 216 | 40 | 108 | 88 | 85 |
Pool B SBP | Placebo | AZL-M 40 mg | AZL-M 80 mg | VAL 320 mg | Placebo | AZL-M 40 mg | AZL-M 80 mg | VAL 320 mg | Placebo | AZL-M 40 mg | AZL-M 80 mg | VAL 320 mg |
Baseline (mmHg) | – | 145 | 145 | 145 | – | 144 | 144 | 145 | – | 144 | 145 | 146 |
Δ (mmHg) | – | −15.0 ± 0.8§ | −15.4 ± 0.8§ | −11.1 ± 0.8 | – | −13.3 ± 0.8†† | −15.1 ± 0.9§ | −10.9 ± 0.8 | – | −11.8 ± 1.1 | –12.0 ± 1.2 | –10.1 ± 1.2 |
Pool B DBP | Placebo | AZL-M 40 mg | AZL-M 80 mg | VAL 320 mg | Placebo | AZL-M 40 mg | AZL-M 80 mg | VAL 320 mg | Placebo | AZL-M 40 mg | AZL-M 80 mg | VAL 320 mg |
Baseline (mmHg) | – | 90 | 89 | 89 | – | 86 | 87 | 87 | – | 83 | 86 | 87 |
Δ (mmHg) | – | −9.8 ± 0.6‡ | −10.0 ± 0.5† | −7.4 ± 0.6 | – | −8.2 ± 0.6 | −9.7 ± 0.6† | −6.9 ± 0.6 | – | −6.8 ± 0.7 | −7.7 ± 0.8 | −6.0 ± 0.8 |
N | – | 211 | 215 | 199 | – | 202 | 175 | 201 | – | 102 | 99 | 96 |
Data are LS mean ± standard error (SE). AZL-M, azilsartan medoxomil; OLM, olmesartan; VAL, valsartan. Δ = change from baseline.
*P ≤ 0.001 versus placebo.
†P ≤ 0.01 versus OLM/VAL.
‡P < 0.05 versus OLM/VAL.
§P ≤ 0.001 versus OLM/VAL.
††P = 0.03 versus VAL.