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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Prog Biophys Mol Biol. 2016 Jun 19;121(2):185–194. doi: 10.1016/j.pbiomolbio.2016.06.004

Fig. 1.

Fig. 1

Multi-scale modeling of rabbit cardiac electrophysiology. (A) Family of simulated rabbit ventricular myocyte APs and intracellular calcium ([Ca2+]) transients, produced using the model by Mahajan, Shiferaw et al. (Mahajan et al., 2008). Physiologically-relevant variability in shape and duration was achieved by using hundreds of stochastically-generated parameter combinations to modify behavior of repolarizing currents (Gemmell et al., 2014). APD50 and APD90 ranges are shown as blue and red shaded areas, respectively. (Reprinted with permission from (Gemmel et al., 2014)). (B) UC San Diego rabbit heart geometry with tetrahedral element edges shown in inset. (C) Structurally-detailed rabbit mesh of the rabbit ventricles including an image-based representation of the free-running Purkinje system (pink). (Reprinted with permission from (Vadakkumpadan et al., 2009))