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. 2016 Jul 18;7:272. doi: 10.3389/fimmu.2016.00272

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Copyright © 2016 Ebersole, Kirakodu, Novak, Orraca, Martinez, Cunningham, Thomas, Stromberg, Pandruvada and Gonzalez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap depicting the distribution of correlations of B cell/plasmacyte genes with tissue destructive genes (MMP2, MMP9, CTSK, TNF, and RANKL) in healthy gingival tissues (H, n = 23) and periodontitis tissues (PD, n = 11) of adult and aged animals. The graph displays differences in gene expression in the adult and aged tissues compared with control levels displayed in a group of 10 healthy animals from 3 to 7 years of age. Green denotes negative correlation and red denotes positive correlation with the expression of the tissue destructive genes. The brackets signify the nine gene clusters created based on similarity indices of 0.4–0.5.