Table 1.
Identification of the top 50 upregulated genes in periodontitis versus healthy gingival tissues related to adaptive immune responses.
| Human | Non-human primate | ||
|---|---|---|---|
| Gene ID | r(i) | Gene ID | r(i) |
| V-DXP4-JH6c | 24.7 | IGHV-III VH26 | 10.29 |
| IGKVJ | 14.39 | IGHV-II SESS | 8.87 |
| IGVH1 | 12.43 | VPREB2 | 8.64 |
| V-DK4-JH4b | 12.33 | IGKV-1 HK102 | 8.49 |
| C-D-JH6 | 11.84 | IGKV-11 RPMI6410 | 7.69 |
| IGL | 11.22 | CD179b | 7.57 |
| IGK-3D-15 | 8.6 | IGKV-1 HK101 | 6.17 |
| IGLV2-23*01 | 8.2 | KLRC1 | 6.16 |
| MUC5AC | 8.08 | MMP3 | 5.81 |
| NHPHL7 | 6.9 | IGHV4-1 | 5.75 |
| SCYB6 | 6.16 | IGLV-I BL2 | 5.73 |
| GRO1 | 6.1 | ZLG | 5.49 |
| IGLJ3 | 6.03 | PIP | 5.41 |
| TMEM156 | 5.89 | IGLV-II MGC | 5.2 |
| IGHG3 | 5.78 | IGHA2 | 5.19 |
| PABL | 5.42 | FAM123A | 5 |
| KYNU | 5.4 | CLDN8 | 4.75 |
| IL8 | 5.15 | IGLV-III LOI | 4.73 |
| UBD | 4.71 | IGH | 4.44 |
| VNN1 | 4.62 | IGJ | 4.39 |
| SLU7 | 4.19 | ADCYAP1 | 4.37 |
| IGKVJ | 4.11 | TVB2 CTL-L17 | 4.35 |
| IGVH4 | 3.9 | IGHV-II ARH-77 | 4.26 |
| CPD | 3.79 | IGHV | 4.26 |
| PLAC8 | 3.51 | POU2AF1 | 4.25 |
| IGKVJC | 3.49 | APOE | 4.23 |
| SOD2 | 3.45 | MCART6 | 4.15 |
| IGK | 3.34 | IL19 | 4.13 |
| IGLP3 | 3.27 | hmRNPA1 | 4.12 |
| CASP3 | 3.11 | CXCL1 | 4.05 |
| MS4A2 | 3.06 | CCL20 | 4.05 |
| CD20 | 3 | IGLL1 | 4.04 |
| MDM4 | 2.89 | KLRF1 | 3.87 |
| PLAT | 2.87 | COX6C | 3.75 |
| GLDC | 2.81 | HLA-DOB | 3.7 |
| CEACAM1 | 2.71 | FAM30A | 3.64 |
| YES1 | 2.62 | FOSB | 3.57 |
| PTH | 2.53 | CENPT | 3.53 |
| XBP1 | 2.49 | SPATA4 | 3.52 |
| FMO2 | 2.47 | FAM46C | 3.49 |
| SOD2 | 2.45 | IGL | 3.43 |
| PSME4 | 2.44 | SPAST | 3.39 |
| SLC1A1 | 2.41 | IGHG1 | 3.39 |
| C20orf67 | 2.38 | TNNI2 | 3.38 |
| HS3ST1 | 2.38 | LILRA1 | 3.38 |
| CLCA4 | 2.34 | IGLV-II BUR | 3.38 |
| GPR65 | 2.34 | BANK1 | 3.37 |
| PHLDA1 | 2.33 | IGHV-I V35 | 3.36 |
| HSP13A | 2.16 | IRF4 | 3.27 |
| SLP76 | 2.15 | TACI | 3.27 |
| IGA1C | 2.13 | IGK | 3.26 |
Genes highlighted in yellow associated with adaptive immune responses.