Table 3.
Gene expression differences in adult and aged healthy and periodontitis tissues related to average gene response patterns in healthy tissue samples from animals 3–7 years of age (correlates with 11- to 25-year-old human).
| Fold difference | |||||
|---|---|---|---|---|---|
| Gene ID | Adult H | Aged H | Adult PD | Aged PD | Fxn. Categorya |
| CCR1 | 1.2 | 1.8 | 2.4 | 3.1 | 2 |
| CD19 | 1.7 | 2.5 | 2.8 | 5.2 | 1 |
| CD28 | 1.5 | 1.8 | 2.0 | 4.3 | 1 |
| CD20 (MS4A1) | 1.1 | 3.3 | 3.2 | 7.3 | 2.4 |
| CR2 (CD21) | 1.4 | 3.7 | 3.5 | 12.8 | 1 |
| CTLA4 | 1.2 | 1.8 | 2.3 | 3.8 | 1 |
| FOS | 0.8 | 1.5 | 4.4 | 3.7 | 1 |
| ICAM2 | 1.1 | 1.4 | 1.3 | 1.7 | 3 |
| IGHG1 | 2.2 | 6.3 | 4.2 | 18.5 | 4 |
| IGHM | 2.5 | 7.4 | 12.2 | 16.9 | 4 |
| IGHV2 ARH-77 | 1.6 | 2.4 | 5.1 | 10.8 | 4 |
| IGHV3 VH26 | 1.3 | 1.8 | 3.2 | 7.1 | 4 |
| IGHV4-1 | 0.9 | 1.8 | 3.2 | 8.5 | 4 |
| IGJ | 2.4 | 5.5 | 14.9 | 18.6 | 4 |
| IGKC | 1.3 | 2.9 | 2.1 | 10.4 | 4 |
| IGKV1 HK102 | 3.1 | 4.1 | 14.6 | 27.9 | 4 |
| IGLV2 BUR | 2.6 | 5.5 | 10.9 | 15.5 | 4 |
| IGLV3 LOI | 3.0 | 6.7 | 14.6 | 28.7 | 4 |
| IGLL1 | 1.9 | 3.7 | 5.4 | 11.5 | 4 |
| IRF4 | 1.8 | 3.2 | 6.0 | 9.7 | 4 |
| LRMP | 1.2 | 1.5 | 2.1 | 3.3 | 3.4 |
| POU2AF1 | 2.8 | 5.1 | 10.4 | 21.4 | 1 |
| SELL | 1.7 | 2.7 | 4.4 | 5.0 | 5 |
| TNFRSF13B | 1.4 | 2.1 | 2.5 | 4.0 | 2.4 |
| TNFRSF17 | 3.0 | 5.8 | 9.6 | 22.3 | 4 |
| VAV1 | 1.4 | 2.1 | 2.9 | 4.0 | 3 |
aFunctional categories denoted as 1 – antigen-dependent activation; 2 – cell activation; 3 – cell proliferation; 4 – differentiation/maturation; 5 – plasmacyte; 6 – multiple functions.