Table II.
Comparison of cytokine concentrations in exhaled breath condensate unadjusted and adjusted for pre-EBC collection FEV1. Associations between cytokine concentrations with positive exercise-induced bronchoconstriction (EIB) adjusted for the effects of: age, gender, presence of atopy, allergic rhinitis, FeNO level and intensity of current anti-asthma therapy. Data are presented with median value (interquartile range) and adjusted odds ratios (OR)
| Parameter [pg/ml] | EIB negative (n = 15) |
EIB positive (n = 10) |
ORa | P-value for unadjusted values | P-value for adjusted values | ||
|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted | Unadjusted | Adjusted | ||||
| IL-4 | 25.8 (15.4–77.9) |
0.11 (0.08–0.39) |
14.3 (12.1–21.3) |
0.06 (0.05–0.08) |
0.001 | 0.154 | 0.079 |
| IL-5 | 56.8 (37.2–75.6) |
0.41 (0.15–0.58) |
47.7 (29.0–74.7) |
0.19 (0.09–0.38) |
0.19 | 0.709 | 0.219 |
| IL-6 | 17.7 (6.9–30.7) |
0.15 (0.09–0.17) |
23.3 (18.0–31.1) |
0.12 (0.10–0.16) |
36.3 | 0.285 | 0.815 |
| IL-8 | 6.0 (3.1–7.9) |
0.03 (0.01–0.03) |
4.8 (4.5–6.2) |
0.02 (0.02–0.02) |
23451 | 1.000 | 0.907 |
| IL-13 | 18.7 (3.3–26.5) |
0.05 (0.02–0.08) |
21.5 (18.8–25.0) |
0.06 (0.05–0.08) |
11012 | 0.508 | 0.291 |
| IL-15 | 29.8 (6.9–42.8) |
0.24 (0.16–0.45) |
46.5 (23.6–54.6) |
0.34 (0.23–0.46) |
4.81 | 0.312 | 0.320 |
| IL-16 | 7.1 (4.6–11.1) |
0.22 (0.14–0.30) |
14.2 (8.3–18.8) |
0.36 (0.24–0.52) |
133651 | 0.074 | 0.017 |
| MCP-1 | 40.7 (17.2–67.8) |
0.17 (0.11–0.29) |
84.2 (58.6–103.5) |
0.42 (0.38–0.64) |
325 | 0.042 | 0.022 |
| MIG | 436 (287–660) |
1.02 (0.55–1.27) |
530 (408–579) |
0.83 (0.50–1.94) |
1.45 | 0.437 | 1.000 |
| TNF-α | 137 (107–154) |
0.42 (0.18–0.63) |
137 (77–190) |
0.27 (0.20–0.41) |
1.19 | 0.841 | 0.815 |
a
Odds ratio for positive EIB (as dependent variable) adjusted for age, gender, presence of atopy, allergic rhinitis, FeNO level and intensity of current anti-asthma therapy.