Table II.
Changes in pre-stroke medications in recurrent stroke patients in the analyzed periods
| Pre-stroke medications | Years 1995–1999 | Years 2000–2004 | Years 2005–2009 | Years 2010–2013 | Overall p |
||||
|---|---|---|---|---|---|---|---|---|---|
| N | Value | N | Value | N | Value | N | Value | ||
| Antihypertensives, n (%) | 104 | 73 (70.2) | 269 | 199 (74.0) | 285 | 229 (80.4)a | 191 | 160 (83.8)a | 0.013 |
| In patients with preexisting HTN, n (%) | 83 | 73 (88.0) | 220 | 194 (88.2) | 245 | 218 (89.0) | 168 | 151 (89.9) | 0.950 |
| Antiplatelets, n (%) | 105 | 52 (49.5) | 269 | 146 (54.3) | 278 | 168 (60.4) | 186 | 118 (63.4)a | 0.057 |
| Vitamin K antagonists, n (%) | 105 | 5 (4.8) | 268 | 24 (9.0) | 283 | 39 (13.8)a | 186 | 29 (15.6)a | 0.012 |
| In patients with preexisting AF, n (%) | 28 | 4 (14.3) | 81 | 15 (18.5) | 102 | 27 (26.5) | 66 | 19 (28.8) | 0.265 |
| Statins, n (%) | – | – | 123 | 40 (32.5) | 273 | 106 (38.8) | 187 | 111 (59.4)b | < 0.001 |
a
Significant difference compared with period 1995–1999
b
significant difference compared with preceding time period
AF – atrial fibrillation.