Table II.

Changes of TSH in two groups and the therapeutic dose of Letrox

Time	TSH [mIU/l]		L-thyroxine [µg/day]
	Treatment group	Control group	Treatment group
Baseline	13.72 ±2.29*	7.09 ±1.23	12.5 ±0.0
1 month	7.71 ±2.36#	7.02 ±1.24	23.2 ±5.2
2 months	5.22 ±1.48*#	7.16 ±1.23	24.5 ±6.1
3 months	4.60 ±1.24*#	7.65 ±1.36	25.5 ±6.1
6 months	4.21 ±0.78*#	7.89 ±1.32	25.7 ±7.6+
12 months	4.18 ±0.71*#	8.05 ±1.37	26.3 ±7.3
18 months	4.14 ±0.77*#	8.15 ±1.53	26.8 ±9.1
24 months	4.15 ±0.82*#	8.29 ±1.50	27.3 ±9.9
30 months	4.08 ±0.64*#	8.30 ±1.38	28.0 ±9.9
36 months	4.10 ±0.62*#	8.35 ±1.45	28.0 ±9.9

Data are presented as mean ± SD

^*P < 0.001 vs. control group

^#P < 0.001 vs. baseline

⁺The dose was decreased in two patients because of angina.