Table 4.
Effects of CCC, CFCC, and CAF treatments on the Drosophila melanogaster mean lifespan and healthspan.
| Mean lifespan (days) | Mean lifespan difference (%)a | Healthspan (80th percentile) (days) | Healthspan difference (%)a | |
|---|---|---|---|---|
| CCC (mg/mL) | ||||
| Control | 59.68 ± 2.92 | 0 | 32.63 ± 1.49 | 0 |
| 0.78 | 59.7 ± 2.6 | 0.04 | 29.67 ± 2.28 | −9.08 |
| 3.125 | 69.78 ± 2.82∗∗ | 16.93 | 37.73 ± 2.58 | 15.63 |
| 6.25 | 59.81 ± 2.58 | 0.23 | 37.30 ± 2.26 | 14.32 |
| 25 | 69.16 ± 3.39∗ | 15.90 | 34.48 ± 2.17 | 5.57 |
| 100 | 64.34 ± 3.77 | 7.82 | 39.95 ± 0.96∗ | 22.44 |
|
| ||||
| CFCC (mg/mL) | ||||
| Control | 66.05 ± 2.17 | 0 | 46.30 ± 1.90 | 0 |
| 0.78 | 65.7 ± 3.23 | −0.99 | 42.16 ± 3.42 | −8.93 |
| 3.125 | 66.86 ± 2.03 | 1.01 | 39.00 ± 5.00 | −15.77 |
| 6.25 | 59.55 ± 3.57 | −9.84 | 52.05 ± 1.93∗ | 12.43 |
| 25 | 66.06 ± 2.7 | 1.0 | 42.30 ± 0.67 | −8.64 |
| 100 | 54.71 ± 2.17∗∗∗ | −18.17 | 38.27 ± 1.09 | −17.35 |
|
| ||||
| CAF (mM) | ||||
| Control | 58.84 ± 2.46 | 0 | 30.18 ± 1.15 | 0 |
| 0.004 | 62.88 ± 1.7 | 6.87 | 47 ± 2.65∗∗ | 55.73 |
| 0.016 | 64.34 ± 2.75 | 9.35 | 36.18 ± 3.57 | 19.87 |
| 0.032 | 68.86 ± 2.38∗∗ | 17.02 | 42.35 ± 3.57∗ | 40.32 |
| 0.127 | 70.91 ± 2.99∗∗∗ | 20.52 | 36.91 ± 3.22 | 22.23 |
| 0.51 | 61.14 ± 2.07 | 3.91 | 38.15 ± 2.2∗ | 26.41 |
aThe difference was calculated by comparing treated flies with the concurrent water control. Positive numbers indicate lifespan increase and negative numbers indicate lifespan decrease. Data are expressed as mean value ± SE. ∗ p ≤ 0.05, ∗∗ p ≤ 0.01, and ∗∗∗ p ≤ 0.001 significances obtained with the log-rank (Mantel-Cox) test.