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. 2016 Jul 15;6(7):e009809. doi: 10.1136/bmjopen-2015-009809

Table 1.

Characteristics of the individual studies included in this systematic review and meta-analysis

First author year of publication Location Age
years
Male (%) Sample size Study design Exposure definition Adjustments Outcome
Muckadell 197632 Denmark 40–59 100 312 Case–control NA NA Gout (physician diagnosed)
Curb 198633 USA 54.1 100 5858 Cohort 0 cups/day, 1–2 cups/day, 3–4 cups/day, 5–6 cups/day, 7–8 cups/day, >9 cups/day NA SUA
Kiyohara 199934 Japan 52.0 100 2240 Cross-sectional <1 cup/day, 1–2 cups/day, 3–4 cups/day, >5 cups/day Hospital, age, serum total cholesterol, serum HDL-cholesterol, serum creatinine, systolic blood pressure, BMI, rank, beer, alcohol, smoking status, meat, dairy products and green tea SUA
Yuan 200035 Taiwan NA NA 96 Case–control Ever, never NA SUA
Choi 200737 USA 54.0 100 45 869 Cohort 0 cups/day, <1 cup/day, 1–3 cups/day, 4–5 cups/day, >6 cups/day Age, total energy intake, BMI, diuretic use, history of hypertension, history of renal failure, intake of alcohol, total meats, seafood,
purine-rich vegetables, dairy foods, total vitamin C, decaffeinated coffee, tea
Gout (gout criteria of the American College of Rheumatology)
Choi 200736 USA 45.0 46.8 14 758 Cross-sectional 0 cups/day, <1 cup/day, 1–3 cups/day, 4–5 cups/day, >6 cups/day Age, sex, smoking status, BMI, smoking; use of diuretics, β-blockers, allopurinol, uricosuric agents, hypertension,
glomerular filtration rate, alcohol, total meats, seafood, dairy foods, decaffeinated coffee, tea
SUA, HU (SUA level >6.0 mg/dL)
Choi 201038 USA 46.0 0 89 433 Cohort 0 cups/day, <1 cup/day, 1–3 cups/day, >4 cups/day Age, total energy intake, BMI, menopause, use of hormonal replacement, diuretic use, history of hypertension, intakes of alcohol, sugar-sweetened soft drinks, total meats, seafood, chocolate, dairy foods, total vitamin C, decaffeinated coffee, tea Gout (gout criteria of the American College of Rheumatology)
Pham 201039 Japan 62.3 42.6 11 662 Cross-sectional 0 cups/day, <1 cup/day, 1–3 cups/day, 4–6 cups/day, ≥7 cups/day Age, BMI, smoking, alcohol use, work-related physical activity, leisure-time physical activity, hypertension, diabetes, eGFR, seafood intake SUA, HU (SUA level >7.0 mg/dL)
Chuang 201140 Taiwan >19 47.5 4640 Cross-sectional NA NA SUA, HU (SUA level >7.7 mg/dL in men and >6.6 mg/dL in women, or use of uric acid-lowering drugs) gout (self-report)
Teng 201341 Singapore 57.6 44.3 483 Cross-sectional Non-drinkers, monthly drinkers, weekly drinkers, daily drinkers Cholesterol, creatinine, HbA1c, triglycerides, age, gender, BMI, education, cigarette smoking status, physical activity status, hypertension at baseline, dairy products, red meat, fish, alcohol, green tea, black tea, soda, fruit juice SUA, HU (SUA level >6 mg/dL)
Bae 201542 Korea 61.9 37.9 9400 Cross-sectional <0.1 g/day, 0.1–2.1 g/day, 2.2–4.1 g/day, 4.2–8.1 g/day, ≥8.2 g/day in males; <0.1 g/day, 0.1–0.6 g/day, 0.7–2.7 g/day, 2.8–4.1 g/day, ≥4.2 g/day in females (g/day means grams of coffee consumed every day) Age, education, marital status, cigarette smoking, alcohol drinking, regular exercise, BMI, triglyceride, fasting serum glucose, hypertension medication, glomerular filtration rate, total energy, vitamin c, meat intake, seafood intake, dairy food intake, soft drink intake, added sugar in coffee, added cream in coffee. SUA, HU (SUA>7.0 mg/dL in males and >6.0 mg/dL in females)

BMI, body mass index; eGFR, estimated glomerular filtration rate; HbA1c, glycated haemoglobin; HDL, high-density lipoprotein; HU, hyperuricaemia; NA, not available; SUA, serum uric acid.