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. 2015 Jul 13;13(4):524–534. doi: 10.1038/cmi.2015.47

Figure 2.

Figure 2

Pdcd4 deficiency decreased the expression of IL-17 in CD3-stimulated T cells in vitro. Pdcd4+/+Apoe−/− and Pdcd4−/−Apoe−/− mice were fed a high fat diet between age 8 weeks to 16 weeks. The splenocytes were stimulated with anti-CD3 monoclonal antibody (5 μg/mL) in vitro for 3 days. (a) The concentrations of IL-2, IL-4, IL-6, IFN-γ, TNF-α, IL-17, and IL-10 in the culture supernatants were detected using the BD CBA Mouse Th1/Th2/Th17 Cytokine Kit. (b) The differences in the concentrations of IL-17 between two genotypes of mice were analyzed using an unpaired t-test. The data are shown as the means ± SEM. *P < 0.05. The data are derived from six Pdcd4+/+Apoe−/− mice and four Pdcd4−/−Apoe−/− mice.