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. 2015 Jul 13;13(4):524–534. doi: 10.1038/cmi.2015.47

Figure 5.

Figure 5

Blockage of IL-10, but not additional recombinant IL-17, partially reversed the reduced aortic lesion in Pdcd4−/−Aope−/− mice. After being fed a high fat diet for 4 weeks, the Pdcd4−/−Apoe−/− mice were divided into two groups. One group received an injection of exogenous recombinant IL-17 or neutralizing IL-10 Ab, while the other group received injection of normal saline or isotype IgG as controls. The control Pdcd4+/+Apoe−/− mice received only the injection of normal saline or isotype IgG. The degree of IL-17 supplementation (a) and IL-10 sequestration (b) was determined in the serum of the Pdcd4−/−Apoe−/− mice using ELISA. The serial frozen sections of the aortic roots after treatment with exogenous recombinant IL-17 (c) or neutralizing IL-10 Ab (d) stained with H&E are shown. (e–f) The aortic lesion areas were measured using Image Proplus 6.0 software. The data are shown as the means ± SEM. P values of ANOVA for three groups were both less than 0.001. *P < 0.05; ***P < 0.001. The data are derived from four mice per group.