. 2016 Jul 18;6:29427. doi: 10.1038/srep29427

Table 3. Association of the clinical covariates with MRD status at different time points.

Time point	Clinical covariates	MRDFC			MRDFC/RQ
Time point	Clinical covariates	Negative	Positive	P	Negative	Positive	P
Day 15	ALL IC-BFM 2002/2009 risk group
	SR	11	32	0.067	12	36	0.044¹
	IR	9	60		9	64
	HR	1	22		2	31
Day 33	t(9;22)/BCR-ABL and/or t(4;11)/MLL-AF4
	negativity	95	19	0.001¹	100	27	<0.001¹
	positivity	2	6	0.001¹	2	9	<0.001¹
	Bone marrow morphology at day 15
	M1/M2	100	24	0.002¹	106	35	0.001¹
	M3	0	4	0.002¹	1	7	0.001¹
	Prednisone response
	good	95	25	>0.1	100	34	0.017¹
	poor	5	3	>0.1	7	9	0.017¹
	Bone marrow morphology at day 33
	M1	98	25	0.069	105	39	0.057
	M2/M3	2	3	0.069	2	4	0.057
	ALL IC-BFM 2002/2009 risk group
	SR	40	3	<0.001¹	44	6	<0.001¹
	IR	52	12		53	14
	HR	8	13		10	23
Week 12	t(9;22)/BCR-ABL and/or t(4;11)/MLL-AF4
	negativity	97	2	0.021¹	107	2	<0.001¹
	positivity	5	2	0.021¹	5	4	<0.001¹
	Bone marrow morphology at day 15
	M1/M2	107	2	0.001¹	121	3	0.007¹
	M3	0	2	0.001¹	2	2	0.007¹
	ALL IC-BFM 2002/2009 risk group
	SR	35	0	<0.001¹	41	0	<0.001¹
	IR	61	0		65	0
	HR	11	4		17	6

SR, standard risk; IR, intermediate risk; HR, high risk. Only P-values <0.1 were included in the table.

¹Results statistically significant (P < 0.05, 2-sided Fisher exact probability test).