Table 3. Genotype and allele distribution of rs2070699 in 112 neonates.
| PPHN | non-PPHN | χ2 | P | OR | 95% CI | |
|---|---|---|---|---|---|---|
| Genotype frequency | ||||||
| GG | 12(21.8) | 30(52.6) | 11.339 | 0.001 | 0.25 | 0.11, 0.57 |
| GT | 26(47.3) | 23(40.4) | 0.545 | 0.460 | 1.33 | 0.63, 2.80 |
| TTΨ | 17(30.9) | 4(7.0) | 10.488 | 0.001 | 5.93 | 1.85, 19.03 |
| Allele frequency | ||||||
| G | 50(45.5) | 83(72.8) | ||||
| T | 60(54.5) | 31(27.2) | 31.797 | 0 | 3.89 | 1.96, 7.72 |
*The Chi-square test was used. Odds ratios and 95% CI were estimated using an additive model. As to END1 gene, the T allele of rs2070699 was more prevalent in PPHN patients compared to control subjects after Bonferroni-Dunn’s multiple comparisons post-hoc analysis for test groups (0.05/3), there revealed significant differences in frequencies of G/T alleles. CI: confidence interval.
Ψχ2-Fisher’s Exact test.